Comedy Central issued a statement, saying, "The tragic news of Greg's passing hits us very, very hard. Greg has been a close member of the Comedy Central family for years, injecting his energy and wicked sense of humor into countless projects. The comedy community lost a brother today. Our thoughts are with his family."
Giraldo had been hospitalized since Saturday in New Jersey after an accidental overdose on prescription pills.
Fellow comic Jim Norton tweeted about Giraldo's death Wednesday afternoon with a photo taken of the two at a June 28 wedding.
Giraldo was known for his Comedy Central roasts and appeared on "The Howard Stern Show," among others.
The comedian, who attended Harvard, was a father of four.
– The Hollywood Reporter