The actor-turned-children's author, who was diagnosed with dyslexia as an adult, said he was "overwhelmed" to have his work recognized.
In the past two years, he has toured schools in the U.K., talking about the learning disability.
Winkler posted a photograph of himself sporting his medal on Twitter: "Here I am with my OBE pinned on very honored very proud…"
He spoke to BBC Breakfast of his delight at the "unexpected" honor.
"I got a letter from the Queen saying she graciously agreed to confer on me the OBE," he said.
He is the author of the "Hank Zipzer" children's book series, which features a young dyslexic protagonist.
Zipzer's adventures are based on Winkler's own childhood struggles with school and the resulting bullying.
The author said visiting U.K. schools was "one of his favorite things to do".
British ambassador Nigel Sheinwald presented the OBE to Winkler during the ceremony at the embassy.
Mr Sheinwald said: "Through [Winkler], thousands of young people have seen a role model and an inspiration for overcoming their learning challenges."
The Queen makes honorary awards to non-British citizens on the advice of the U.K. Foreign Office. It is not clear whether she is a fan of the Fonz.
– The Hollywood Reporter