Eclipse was named favorite overall movie, as well as favorite drama. Stars Kristen Stewart, Robert Pattinson and Taylor Lautner took home the award for favorite onscreen team, with Stewart also winning actress honors.
Also in the movie categories, Johnny Depp was honored as favorite actor, Jackie Chan as action star and Adam Sandler as comedy actor.
"Toy Story 3" was voted favorite family movie.
House, meanwhile, took home honors for favorite TV drama; favorite dramatic actor and actress for Hugh Laurie and Lisa Edelstein; and favorite TV doctor for Laurie's character, Gregory House.
"Glee" was voted top TV comedy, with star Jane Lynch named favorite comedy actress. "How I Met Your Mother's" Neil Patrick Harris won comedy actor honors.
Eminem's haul also included two awards for "Love the Way You Lie," his song with Rihanna, which won for favorite song and music video. Rihanna also was named favorite pop artist.
Other honorees in the music categories included double winner Katy Perry, favorite female artist and favorite online sensation. Usher and Taylor Swift took home the R&B and country awards, respectively.
The People's Choice Awards, hosted by Queen Latifah, took place at the Nokia Theatre in downtown Los Angeles.
The Associated Press contributed to this report.
– The Hollywood Reporter